You may have difficulty with the string of topics and how they tie together, but stay with me. They most certainly do. These and so many more. Too many to be able to present them all in one post, or even one series. These folks have their hand in every single aspect of our world. They are power hungry, blood thirsty, narcissistic maniacs. They claim to be of the bloodline/lineage of the Fallen Angels and/or their Progeny. I believe it. They are pure evil. I know that is hard for people to accept. We all want to see the good in everyone. BELIEVE ME, there are people in this world that ARE PURELY EVIL. They have no redeeming qualities and they are not eligible for salvation. When you open your eyes and allow yourself to really see their works, there will be no doubt.
Just remember, Satan often comes as an Angel of Light, and evil is often done under the PRETENSE of doing something good. Things are no always what they seem. We often find ourselves paying the price years down the road for trusting in something that appeared to be a good thing at the time.
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What is pharmakeia in the Bible?
The Greek word pharmakeia appears in Galatians 5:20 and Revelation 18:23. Terms from the same root word appear in Revelation 9:21, Revelation 21:8, and Revelation 22:15. These are typically translated into English as “sorcery,” “witchcraft,” or “sorcerer.” Ancient Greek uses of pharmakeia closely mirror the generic modern English word drugs ; the same Greek root word produced English terms such as pharmacy and pharmacist.
Modern use of the word sorcery evokes images of supernatural power and spells; biblical use of pharmakeia doesn’t fit well with such ideas. Rather, the term suggests various forms of drug abuse. Those might include drug use in pagan worship, as an addiction, or as a poison used to manipulate and control others. (or cause harm or damage to others whether done by an individual or a Corporation or Foundation or Government)
In modern English, separate terms distinguish medicines, chemicals, and illicit drugs. As used in most contexts, a “pharmacist” and a “drug dealer” both distribute chemicals, but of different kinds and for drastically different reasons. Because English vernacular uses entirely different words, phrases like selling drugs evoke something illicit while taking meds or prescription drugs don’t imply anything nefarious. Ancient Greeks used words like pharmakeia to refer to that entire spectrum: from medicines to psychoactives to poisons. This makes cultural and biblical context crucial when interpreting terms related to pharmakeia.
Ancient societies were no stranger to mind-altering chemicals. Archaeologists note the presence of opium, hemp, and many other substances in Bible-era cultures. These compounds were not as potent as modern options but still capable of powerful effects. For example, synthetic drugs like carfentanyl are a hundred thousand times as powerful as an equivalent dose of natural opium—this is what allows a small dart to tranquilize an elephant. But opium itself is still a strong drug.
Mood-altering substances were also used in connection to ancient religious practices. Temples such as those in Greece sometimes used mind-altering drugs in fortune-telling and oracles. These may have included natural vapors and deliberately concocted mixtures. When Paul wrote Galatians and John recorded Revelation, these practices would have been part of pagan idolatry.
Substances that alter a person’s perceptions can be used as legitimate medicines (1 Timothy 4:4). They can also be abused for recreation. Even worse, they can be used in a predatory manner, influencing others and taking advantage of their skewed awareness. The biblical concept of “sorcery” seems to lean toward the latter end of this spectrum. A biblical “sorcerer” could be thought of as the equivalent of a modern “drug dealer.” Or as the type of person who slips chemicals into a woman’s drink to take advantage of her. (Or as corporations that create drugs to injure, harm or destroy life and SELL them as something they are not.)
Galatians 5:20 is part of Paul’s list of contrasts to the fruit of the Spirit (Galatians 5:22–23). That list of works of the flesh (Galatians 5:19–21) does not appear to be random. The references are collected into groups of similar offenses. Paul begins by mentioning sexual sin, then idolatry, then “sorcery”—pharmakeia—and then division, before moving on to drunkenness and debauchery. His reference to pharmakeia is grouped closer to idolatry and sexuality than it is to drunkenness, which hints at the use of illicit drugs in ungodly spiritual practices. (that is pure conjecture, just one man’s opinion/interpretation.)
John’s references might also be connected to pagan worship; Revelation 9:21 comes immediately after a condemnation of idolatry. Yet this reference also sits between mentions of murder and sexual sin. Revelation 18:23 is part of a condemnation of Babylon, referring to its “deception.” The phrasing closely echoes the statement of Nahum 3:4, which refers to “charms.” The Hebrew root word used in Nahum is kesheph. That is used in reference to idolatry and often translated as “sorcery,” and is seen in 2 Kings 9:22, Isaiah 47:9, 12, and Micah 5:12.
Combining these contexts, the exact meaning of pharmakeia isn’t crystal clear, but neither is it completely obscure. There’s no sense that Scripture uses terms such as pharmakeia in reference to supernatural powers. Instead, biblical “sorcery” seems to be about abusing drugs for idolatry, recreation, and/or oppression of others.
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God’s word says he gave us the herbs and plants for our healing. And, though most “medicines” have been concocted from these sources, current technology has (likely as ancients using knowledge given by the fallen) perverted and changed the nature of everything so much, it is hard to find anything that is in the form that GOD made it. We certainly cannot trust institutions or modern scientists and pharmacists. Evil is rampant in the world and where money is involved, corruption reigns supreme. We should look to GOD for our source of healing. Don’t trust anything or anyone else, unless GOD leads you to. In my opinion, Pharmakea is any drug/medication created and/or manipulated by MAN.
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Concord, peace, unity, oath, the United Nations. There is SO MUCH EVIL in Belgium and really the NETHERLANDS in general. If you have been following my posts you are already aware. Just some of the things to bear in mind regarding BELGIUM is that they take great pride in their CONCORD, they are part of the ALLIANCE sworn to by the ROYALS of old. They profess to promote unity and are the creators of the UNITED NATIONS. I have multiple posts on this topic. For a basic understanding of today’s post you might want to check out the following two posts:
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BAAL – BELGIUM – LORD/OWNER/MASTER – ROYAL LINE – 10 Kingdoms
BELGIUM Restored 2/19/22 Belgium,[A] officially the Kingdom of Belgium, is a country in Western Europe. It is bordered by the Netherlands to the north, Germany to the east, Luxembourg to the southeast, France to the southwest, and the North Sea to the northwest. It covers an area of 30,689 km2 (11,849 sq mi) and has a population of more than 11.5 million, making it the 22nd most densely populated country in the world … Click Here to Read More
THE HUNT – NODENS – The First will be Last.
This is a continuation of the series entitled “THE HUNT” I have been trying to get this series finished since the Wuhan VIrus was made public. Just so much going on. This post is primarily about one deity. It is important to dedicate a post to this guy with all that is going on right … Click Here to Read More
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The Chocolate Hands of Belgium by Sasha Alyson Follow @TrojanAid In the late 1800s, the great powers of Europe carved up Africa, grabbing colonies for themselves. One not-so-great power also got involved: The tiny kingdom of Belgium. Belgium itself had no colonial aspirations. But its ruler, King Leopold II, was greedy beyond measure.
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Today, anyone who knows this story might be horrified to walk into a confectionary shop in Antwerp, Belgium’s most populous city, and find chocolate hands on sale.
It is no secret today, the atrocities committed by the King of the Belgians, Leopold II, who ruled from 1865 to 1909, and the one responsible for the maiming and killing of an undetermined number of Congolese – a country he considered his personal property including their lands and minerals.
For many still, this king was even worse than Adolf Hitler for his genocide against the people of the Congo Free State (now Democratic Republic of Congo) especially when you consider the fact that in his entire reign and oppression over the people of Congo, he never stepped in that country.
Leopold was definitely a man of insatiable greed who instituted a very unscrupulous form of accounting for every bullet used by his blood-thirsty soldiers called the Force Publique. They had to, after killing people, hack off their right hands and have them kept for stock-taking.
Left: This boy was named Impongi. Sentries cut off one hand and one foot because his village failed to meet its rubber quota.Right: The seated youth is Mola. His hands were destroyed by gangrene after soldiers tied him too tightly. Beside him is Yola. Soldiers cut off her hand, then claimed it came from a rubber worker they had killed. This photo was used by the missionary Alice Seeley Harris, who campaigned against Leopold in England.
Peter Forbath, a historian says, “The baskets of severed hands, set down at the feet of the European post commanders, became the symbol of the Congo Free State (which was not actually a free state). The collection of hands became an end in itself… brought them to the stations in place of rubber; they even went out to harvest them instead of rubber… They became a sort of currency.”
Today, in Antwerp-Belgium, the city called the capital of chocolate, there is a booming chocolate industry called with the Antwerpse Handjes reflecting a completely sensitive inspiration. The Antwerpse Handjes which many people believe to be trendy and creative at first, is actually a purely insensitive and ill-thought practice that only seems to glorify the brutality of its king.
Ancient myths emanating from Belgium speak of a time where there once lived a mighty giant called Druon Antigon, who terrorized his people by demanding tolls he did not deserve from labourers who worked on lands near the Scheldt river. Anybody who was unable to pay, this giant chopped off their hand and threw it into the river.
His terror grew by the years but he would not always be lucky though. One day, an overwhelmingly brave soldier named Silvius Brabo, in battle with the giant, defeated him and also chopped off his hand and likewise, threw it into the river. Some suggest that the name Antwerp comes from the Dutch for the words hand werpen or “hand throwing”.
In the late 1800s into the early 1900s however, King Leopold II would rule Belgium. Almost a déjà vu, this king exerted his influence over the people of the Congo Free State, although the state was nothing free, reliving similar evils that Antigon encouraged.
Leopold determined to make Congo his and so he did. From 1885 to 1908, King Leopold II used the people of the country to enrich himself by exporting valuable resources such as rubber and ivory out of the country, growing richer through his oppression of them as they worked the fields as labourers.
It was forced labour with a spontaneous punishment for anybody who challenged the system: anyone who refused to work or meet the quotas had their hands severed and presented to officials s proof of the enforcement.
And while the news of Leopold’s horrific regime sparked an international outcry that resulted in his losing control over the state in 1908, the Congo remained a Belgian colony until it regained its independence in 1960.
Over the subsequent years, severed hands interestingly became a symbol of the city of Antwerp, starting first as cookies decorated with sliced almonds, and then later as chocolates filled with praline or marzipan. Outside Antwerp’s city hall today, the Brabo Fountain even features a statue of the hero tossing the giant’s hand.
It will be determined that chocolates from Antwerp tell the stories of a sweet victory by Brabo but it outrightly fails to highlight the even more horrendous role that their king played in Congo in later years. At least, in the case of Antigon, his hand also got to be hacked off and thrown into the same river in which he did of the others he took off but that was not the situation in the case of King Leopold II.
And even worse, the barbarism of King Leopold outnumbered that of Antigon. So, it was an Antigon spirit revived after all.
Now back to the Antwerpse Handjes, how is that anybody, and pretty much so, an entire country, allow for a thing such as this – chocolate that is styled like the chopped hands of people who were oppressed by their king, to fester?
Although they may seem like simple candies, these chocolate hands represent a rather silent yet loud symbol of complexities. There is no doubt that there was a vanquishing victory in the history of the country but facing the reality that there is, how is it even fathomable that Belgium chose to highlight that over the less-than-savory realities exploitation and colonization in the Congo?
In fact, it had to take Belgium almost forever to even admit and apologize for all the harm it caused in the Central African region, where it ruled predominantly.
The hand-shaped chocolates are still in circulation. The memories of the days of oppression by King Leopold exist eternally in and on the minds of the people of DRC. Should there be a balance and should there be some honesty in these overly stated facts of what happened?
I would wish that for whatever motivations the country of Belgium derives from continuing to remind the entire world of something that they shouldn’t even be proud of in the first place, through the production of these chocolates, they will prove to everyone that indeed, they are remorseful. It’s a simple thing – stop the production of the hand-shaped chocolates.
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Hand of Druon Antigoon
The legendary giant’s severed hand sits on Antwerp’s popular shopping street.
The city of Antwerp bought de Miller’s work in 1991, but they didn’t want the whole thing, just the hand—and they had a reason for it. A local legend in Antwerp holds that there was once a villainous giant named Druon Antigoon who demanded a toll from those crossing the Scheldt River. If they could not pay, he would cut off one of their hands. According to the story Druon Antigoon carried on this way until a young Roman soldier defeated him, severing the giant’s own hand and throwing it into the river. This episode is said to be the origin of the city’s name, which comes from hand werpen, Dutch for “hand-throwing.”
(why do the Dutch even have a word for “hand throwing”?)
The sculpture was introduced to the central shopping street of Meir in 1992, with no base whatsoever, in spite of the sculptor’s wishes. Over the years it has become a sort of icon in the area—though not as popular or famous as the Brabo Fountain, which is based on the same legend.
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VISITING THE PRETTY GROTE Market of Antwerp
Tourists are always impressed by the extravagant 16th-century city hall and guildhalls that surround the historic main square. And then they take a closer look at the central fountain, which for those unfamiliar with local legend is quite a peculiar sight: a naked man in the act of throwing a huge severed hand.
The Brabo Fountain (Brabofontein in Dutch) is a tribute to the mythical Roman soldier Silvius Brabo. According to legend, there was once a giant named Druon Antigoon who built a fortress along the Scheldt River. The giant forced passing boats to pay a toll, as well as anyone crossing the nearby bridge. If the travelers refused, Antigoon cut off one of their hands and tossed it into the river.
The giant’s reign of extortion came to an end when Silvius Brabo sailed down river. He refused to pay the giant’s toll, and challenged the giant to a duel. Brabo was victorious, and chopped off the giant’s head as well as his hand, which he threw into the river just like the giant once did.
According to folklore, the name Antwerp—or Antwerpen in Dutch— came from this very legend, with Antwerpen in Flemish and hand werpen in Dutch both meaning “hand throwing.” This has been contested by etymologists, but the legend nonetheless is much celebrated in the city, as evidenced by the fountain and Antwerp’s famous chocolate hands.
The sculpture of Brabo depicts the soldier as he throws the giant’s hand in the river, water spouting out of the severed wrist like blood. Brabo stands on a tall pedestal decorated with an array of creatures, including fish, a sea lion, a turtle, a dragon-like monster and some mermaids holding up a castle, symbolizing Antwerp. And beneath the feet of Silvius Brabo is the severed head of the giant Antigoon, the slain scourge of the now liberated river.
The statue was designed by the Belgian sculptor Jef Lambeaux and inaugurated in 1887. It was placed at the center of the Grote Markt, in a prime location in front of the city hall. Not only did it represent the legend of Silvius Brabo, it was also a symbolic celebration of the freeing of the Scheldt River. For more than a century, the Dutch had been demanding tolls from ships passing along the river, severely hampering the growth of Antwerp. Finally, in 1863, the Dutch stopped demanding tolls (with no dismemberment necessary), a cause for much celebration in Antwerp.
Antwerp is the capital of the Antwerp province in Flanders. The city is about 25 miles north of Brussels.
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Equality with Justice, Informative
Who was King Leopold II?
If you do not recognize that name you are not alone. Leopold II was King of Belgium from 1865-1909. Ever since his coronation in 1865, Leopold II dreamt of capturing the wealth and prestige that other European leaders held. Belgium had only gained independence in 1830, so Leopold II was determined to capture this power by any means necessary. Leopold II came to power when the rest of Europe was in a race to colonize the world under the guise of “spreading Christianity” and “civilizing” the unknown continent of Africa. This race to colonize Africa began in 1885 at the Berlin Conference, where the major European powers met to decide the future for Africa. While the leaders claimed their intentions were only idealistic, their true intentions quickly came to the surface. In the months leading up the conference, Leopold II wrote the Belgian ambassador to Great Britain stating, “I do not want to miss a chance of getting a slice of this magnificent African cake.” Leopold II, ever envious of other European leaders, was awarded the Congo region as his personal property, under the agreement that he would spread Christianity and civilization to the native Congolese people. In reality, Leopold II wanted the land to himself because he knew there were resources and wealth to be gained, but he had no idea just how much.
How did he conquer that much land?
At the time Belgium was governed by a parliament, who did not approve of Leopold’s colonizing mindset, so he circumvented their authority by declaring the “Congo Free State” his personal property. Once Leopold II gained control of Congo, in 1885, he faced the task of exploring and understanding what all the land held. Keep in mind, Congo was seventy-six times the size of Belgium and home to nearly twenty million people. Leopold II hired the famed explorer Henry Morton Stanley to explore the region and make treaties with the native leaders along the way. What history textbooks fail to mention is that these treaties were sleight- of- hand contracts that misled local leaders into signing over their land to Leopold II. Stanley’s numerous expeditions provided the infrastructure for Leopold’s grand vision of colonial conquest. Exploration revealed that the region held vast quantities of rubber and gold.
As the 19th century was drawing to a close, the world experienced a boom in demand for rubber due to the rapid growth in the market for rubber for tires, hoses, and other materials. Refusing to pay the cost of labor to harvest these resources, Leopold II resorted to enslaving the entire population through a wave of terror that forced the Congolese people into submission. Leopold II funded a private army, known as the Force Publique, to set up a system of quotas for harvesting rubber that the people had to meet or face having their limbs cut off. To maintain control over the Congolese, the Force Publique resorted to sadistic tactics such as kidnapping, raping, and slaughtering entire families if they attempted to escape or rebel. In one horrifying instance, a visiting British foreign official remarked, “whole villages and districts I knew well and visited as flourishing communities… are today without human beings.” The same foreign official went on to describe instances of Belgian soldiers looting and burning villages, while also collecting baskets of severed hands to prove that they had not wasted any ammunition. Leopold II instilled fear in his men by requiring a “one bullet one kill” rule to prevent spending his profits on excess ammunition. By the time Leopold II died in 1909, Congo was the most profitable colony in Africa, earning Leopold II an estimated 220 million francs, an equivalent of nearly 1.1 billion dollars today.
So, what does this have to do with statues?
In the years following Leopold II’s death, gold statues were erected throughout Belgium to memorialize the vast amount of wealth that Leopold II amassed, but at what cost? When those statues were being built the Belgian people had a choice. If they owned up to the genocide that was committed to build up their nation’s wealth, it would bring shame to their people. At the time of his death, Belgium had only had its independence for less than a century and did not want to gain the reputation of being a cruel nation that built its wealth on the backs of exploited people.
The Belgians chose to whitewash this stain on their history and only highlight the good that came from Leopold II’s actions.
Instead of acknowledging this gross injustice, their history textbooks push the narrative of Leopold’s bold and idealistic vision of civilizing natives by bringing them Christianity. If a lie is repeated to generation after generation, it will eventually become the accepted truth and part of a nation’s cultural identity.
Janssen Family History Janssen Name Meaning Dutch Flemish North German East Frisian Norwegian and Danish: variant of Jansen . This form has been particularly established in the southeastern Netherlands and adjacent Belgium while it is rare in Norway and Denmark. The surname of Flemish and German origin is also found in the Walloon part of Belgium.
Now, you will see that they are just playing word games with us. As many of these big corporations do. Buying and selling each other under the guise that they are changing hands when they are just playing games to gain tax right offs or conceal underhanded practices or coverup financial gains/losses. The big boys like to hold on to their money.
| Meaning The meaning of Janssen is “Jan’s son”. source the name Janssen means “son of Jan”. source Meaning & History Expand Links Means “son of Jan 1”. Related Names Details Variants Jans, Jansen, Jansens, Jansing, Jansingh, Jansink, Janson, Janssens, Janzen, Yancy sourceThat being the case than JANUS may be the spirit behind this Corporate Name. Jan is just a shortened form of JANUS. THE JANUS KEY
“Janus is the god of beginnings, gates, transitions, time, doorways, passages, and endings. He is usually depicted as having two faces, since he looks to the future and to the past.” wikipedia This post will convince you that they are working very hard to CHANGE our entire beings by polluting and/or altering our DNA. If … Click Here to Read More |
The Pharmaceutical Companies of Johnson & Johnson boldly using science & ingenuity to create a future where disease is a thing of the past. (WELL, THAT SURE ISN’T WORKING!! More diseases now than ever and new ones every day. Even all the old ones are resurrecting!)
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| Industry | Pharmaceutical |
|---|---|
| Founded | 1953 |
| Founder | Paul Janssen |
| Headquarters | Turnhoutseweg 30,
, Belgium
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Number of employees
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10,001 |
| Parent | Johnson & Johnson |
| Website | www.janssen.com |
Janssen Pharmaceuticals is a pharmaceutical company headquartered in Beerse, Belgium, and wholly-owned by Johnson & Johnson. It was founded in 1953 by Paul Janssen.. In 1961, Janssen Pharmaceuticals was purchased by New Jersey-based American corporation Johnson & Johnson, and became part of Johnson & Johnson Pharmaceutical Research and Development (J&J PRD), now renamed to Janssen Research and Development (JRD), which conducts research and development activities related to a wide range of human medical disorders, including mental illness, neurological disorders, anesthesia and analgesia, gastrointestinal disorders, fungal infection, HIV/AIDS, allergies and cancer. Janssen and Ortho-McNeil Pharmaceutical have been placed in the Ortho-McNeil-Janssen group within Johnson & Johnson Company.
Subsidiaries
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- Actelion
- Cilag AG
- Janssen Biotech (formerly Centocor)[1]
- Janssen Vaccines (formerly Crucell)[2]
- Tibotec
- Beijing Dabao Cosmetics Co., Ltd.
History
Janssen (Leiden, 2021)
The early roots of what would become Janssen Pharmaceuticals date back to 1933. In 1933, Constant Janssen, the father of Paul Janssen, acquired the right to distribute the pharmaceutical products of Richter, a Hungarian pharmaceutical company, for Belgium, the Netherlands and Belgian Congo. On 23 October 1934, he founded the N.V. Produkten Richter in Turnhout. In 1937, Constant Janssen acquired an old factory building in the Statiestraat 78 in Turnhout for his growing company, which he expanded during World War II into a four-story building. Still a student, Paul Janssen assisted in the development of paracetamol (USP: acetaminophen, often referred to generically under the trademark Tylenol) under the name Perdolan, which would later become well-known. After the war, the name for the company products was changed to Eupharma, although the company name Richter would remain until 1956.[3]
Paul Janssen founded his own research laboratory in 1953 on the third floor of the building in the Statiestraat, still within the Richter-Eurpharma company of his father. In 1955, he and his team developed their first drug, Neomeritine (ambucetamide), an antispasmodic found to be particularly effective for the relief of menstrual pain. On 5 April 1956, the name of the company was changed to NV Laboratoria Pharmaceutica C. Janssen (named after Constant Janssen). On 27 April 1957, the company opened a new research facility in Beerse, but the move to Beerse would not be completed until 1971–1972. On 2 May 1958, the research department in Beerse became a separate legal entity, the N.V. Research Laboratorium C. Janssen.
On 25 October 1961, the company was acquired by the American corporation Johnson & Johnson. The negotiations with Johnson & Johnson were led by Frans Van den Bergh, head of the board of directors. On 10 February 1964, the name was changed to Janssen Pharmaceutica N.V. and the seat of the company in Turnhout was also transferred to Beerse. The company was led by Paul Janssen, Bob Stouthuysen and Frans Van Den Bergh. When, in 1971-1972 the pharmaceutical production also moved to Beerse, the move from Turnhout was completed. Between 1990 and 2004, Janssen expanded worldwide, and the company grew in size to about 28,000 employees worldwide.
From the beginning, Janssen emphasized as its core activity research for the development of new drugs. The research department which was established in Beerse in 1957, developed into a large research campus. In 1987, the Janssen Research Foundation (JRF) was founded which performs research into new drugs at Beerse and in other laboratories around the globe. Janssen became the Flemish company with the largest budget for research and development. Beside the headquarters in Beerse with its research departments, pharmaceutical production and the administrative departments, Janssen Pharmaceutica in Belgium still has offices in Berchem (Janssen-Cilag), a chemical factory in Geel, and Janssen Biotech in Olen.
The Chemical Production plant in Geel makes the active ingredients for the company’s medicines. In 1975, the first plant of a new chemical factory Plant I was established in Geel, Plant II was opened in 1977, Plant III’ in 1984, and Plant IV in 1995. In 1999 the remaining chemical production in Beerse was transferred to Geel. About 80% of its active components are manufactured here. The site in Geel also manufactures about two-thirds of the worldwide chemical production of the pharmaceutical sector of Johnson & Johnson. In 1995, the Center for Molecular Design (CMD) was founded by Paul Janssen and Paul Lewi.
In 1999, clinical research and non-clinical development become a global organization within Johnson & Johnson. In 2001, part of the research activities was transferred to the United States with the reorganization of research activities in the Johnson & Johnson Pharmaceutical Research Development (JJPRD) organization. The research activities of the Janssen Research Foundation (JRF) and the R.W. Johnson Pharmaceutical Research Institute (PRI) (United States) were merged into the new global research organization. A new building for pharmaceutical development was completed in Beerse in 2001. In 2002, a new logistics and informatics centre was opened at a new site, Beerse 2. In 2003 two new research buildings were constructed, the Discovery Research Center (DRC), and the Drug Safety Evaluation Center (DSEC). On 27 October 2004, the Paul Janssen Research Center, for discovery research, was inaugurated.
In 2011, Johnson & Johnson subsidiary Centocor became Janssen Biotech, part of Janssen Pharmaceuticals.[1]
Also in 2011, Johnson & Johnson acquired Crucell, and assigned it to Janssen. The acquisition of Crucell provided Janssen with a disease prevention arm. By 2014, Crucell was renamed as Janssen Vaccines.[4][2]
In March 2015, Janssen licensed tipifarnib (a farnesyl transferase inhibitor) to Kura Oncology who will assume sole responsibility for developing and commercialising the anti-cancer drug.[5] Later in the same month the company announced that Galapagos Pharma had regained the rights to the anti-inflammatory drug candidate GLPG1690 as well as two other compounds including GLPG1205 (a first-in-class inhibitor of GPR84).[6]
In May 2016, the company launched a collaboration MacroGenics and their preclinical cancer treatment, MGD015. The deal could net MacroGenics more than $740 million.[7]
In September 2017 it was announced that Janssen teamed up with the Biomedical Advanced Research and Development Authority (BARDA), a unit of the U.S. Department of Health and Human Services, to create pandemic flu vaccines. BARDA is giving Janssen $43 million in the first year and $273 million over five years for the contract. One of the projects in the contract is the development of a universal flu vaccine. The intent of the vaccine would be to protect people against all or most flu strains.[8]
On 5 March 2019, the Food and Drug Administration approved Janssen’s Spravato (esketamine nasal spray) for treatment-resistant major depressive disorder. This marked the first approval of a new type of antidepressant in decades.[9]
In 2021, Janssen was named as a defendant in a trial against several opioid manufacturers filed by New York Attorney General Letitia Jame.[10] The company was later removed from the case after Johnson & Johnson agreed to a pay a $230 million settlement to New York State.[11]
Janssen Biotech
The subsidiary Janssen Biotech, Inc. was founded in Philadelphia in 1979 as Centocor Biotech, Inc., with an initial goal of developing new diagnostic assays using monoclonal antibody technology.
Centocor Biotech
In 1982, Centocor transitioned into a publicly traded company.[12] In the early 1980s, the company moved to Malvern, Pennsylvania.[12] In 1984, Centocor opened an overseas plant in Leiden, the Netherlands.[13]
In 1997, eighteen years after its foundation, Centocor achieved its first year of operating profitability.[14][15] In 1998, Centocor sold its diagnostic division to Fujirebio, Inc.[16]
In 1999, Centocor became a wholly owned subsidiary of Johnson & Johnson.[17]
In 2004, Centocor purchased a new manufacturing plant in St. Louis, Missouri, and is currently opening a new manufacturing facility in County Cork, Ireland. The Dutch plant has been expanded substantially with a $250 million investment in additional production facilities, which were opened in 2006.[citation needed]
In 2007, Centocor broke new ground in advertising by releasing Innerstate, believed to be the first theatrically released documentary film both created and entirely funded by a drug company, to promote Remicade (Infliximab).[18]
Centocor Ortho Biotech[edit]
In 2008, Centocor, Inc. and Ortho Biotech Inc. merged to form Centocor Ortho Biotech Inc.
In June 2010, Centocor Ortho Biotech acquired RespiVert, a privately held drug discovery company focused on developing small-molecule, inhaled therapies for the treatment of pulmonary diseases.[19]
As Janssen Biotech
In June 2011, Centocor Ortho Biotech changed its name to Janssen Biotech, Inc. as part of a global effort to unite the Janssen Pharmaceutical Companies around the world under a common identity.[20]
In December 2014, the company announced it would co-develop MacroGenics cancer drug candidate (MGD011) which targets both CD19 and CD3 proteins in treating B-cell malignant tumours. This could net MacroGenics up to $700 million.[21]
In January 2015, the company announced it would utilise Ionis Pharmaceuticals‘ (formerly Isis Pharmaceuticals) Rna-targeting technology to discover and develop antisense drugs targeting autoimmune disorders of the gastrointestinal tract.[22]
In December 2019, XBiotech Inc. announced it would sell its novel antibody treatment (bermekimab) that neutralizes interleukin-1 alpha (IL-1⍺) to Janssen Biotech, Inc.[23][24]
COVID-19 vaccine development
On 27 March 2020, the U.S. Biomedical Advanced Research and Development Authority (BARDA) allocated $456 million for J&J (Janssen) to develop a vaccine against the novel coronavirus.[25][26]
In China
Xi’an-Janssen
Janssen Pharmaceuticals was the first Western pharmaceutical company to set up a pharmaceutical factory in the People’s Republic of China.[27]
In 1976, Paul Janssen met Ma Haide (born George Shafik Hatem), a Lebanese-American doctor who had started working in China in 1933. After three days of meetings, the two agreed to bring a modernized pharmaceutical business to China. When Deng Xiaoping opened China to the West in 1978, Janssen sent Paul Appermont and Joos Horsten to set up the project.[27]
In 1983, Janssen signed a cooperation contract to modernize production in an old chemical factory in the city of Hanzhong, in Shaanxi province. This factory would soon produce the active compound of some Janssen products, such as mebendazole. In 1985, now operating as Xian-Janssen Pharmaceuticals, a new large factory was opened in the city of Xi’an, also in Shaanxi province.[27]
Drugs developed
Risperdal tablets
| R-code | Name | Brand name | Synthetized | Marketed |
|---|---|---|---|---|
| R5 | ambucetamide | Neomeritine | 1953 | 1955 |
| R79 | isopropamide iodide | Priamide-Janssen | 1954 | 1955 |
| R253 | diisopromine | Bilagol | 1955 | 1956 |
| R516 | cinnarizine | Stugeron | 1955 | 1958 |
| R875 | dextromoramide | Palfium | 1955 | 1957 |
| R1132 | diphenoxylate | Reasec | 1956 | 1960 |
| R1625 | haloperidol | Haldol | 1958 | 1959 |
| R2498 | trifluperidol | Triperidol | 1959 | 1961 |
| R3345 | pipamperone | Dipiperon | 1960 | 1961 |
| R3365 | piritramide | Dipidolor | 1960 | 1967 |
| R4263 | fentanyl[28][29] | Sublimaze | 1960 | 1963 |
| R4584 | benperidol | Frenactyl | 1961 | 1965 |
| R4749 | droperidol[30] | Dehydrobenzperidol | 1961 | 1963 |
| R4845 | bezitramide | Burgodin | 1961 | 1971 |
| R6218 | fluspirilene | Imap | 1963 | 1971 |
| R6238 | pimozide | Orap | 1963 | 1970 |
| R7904 | lidoflazine | Clinium | 1964 | 1969 |
| R11333 | bromperidol | Impromen | 1966 | 1981 |
| R12564 | levamisole | Ergamisol | 1966 | 1969 |
| R13672 | haloperidol decanoate | Haldol decanoas | 1967 | 1981 |
| R14889 | miconazole nitrate | Daktarin | 1967 | 1971 |
| R14950 | flunarizine | Sibelium | 1967 | 1977 |
| R15889 | lorcainide | Remivox | 1968 | 1983 |
| R16341 | penfluridol | Semap | 1968 | 1973 |
| R16470 | dexetimide | Tremblex | 1968 | 1972 |
| R16659 | etomidate[31][32] | Hypnomidate | 1964 | 1977 |
| R17635 | mebendazole | Vermox | 1968 | 1972 |
| R18553 | loperamide | Imodium | 1969 | 1973 |
| R33800 | sufentanil[33] | Sufenta | 1974 | 1979 |
| R33812 | domperidone | Motilium | 1974 | 1978 |
| R35443 | oxatomide | Tinset | 1975 | 1981 |
| R39209 | alfentanil[34][35] | Rapifen | 1976 | 1983 |
| R33799 | carfentanil[36] | Wildnil | 1976 | 1980? |
| R41400 | ketoconazole | Nizoral | 1976 | 1981 |
| R43512 | astemizole | Hismanal | 1977 | 1983 |
| R46541 | bromperidol decanoate | Impromen decanoas | 1978 | 1984 |
| R49945 | ketanserin tartrate | Sufrexal | 1980 | 1987 |
| R50547 | levocabastine | Livostin/Livocab | 1979 | 1989 |
| R51211 | itraconazole | Sporanox | 1980 | 1986 |
| R51619 | cisapride | Prepulsid | 1980 | 1989 |
| R64766 | risperidone | Risperdal | 1984 | 1993 |
| R207910 | bedaquiline | Sirturo | 2004 | 2012 |
Janssen Pharmaceuticals has developed and brought to the market about 70 new active substances (NCE), of which the most well-known are (name may differ):
- Imodium (against diarrhoea. Active substance: loperamide)
- Motilium (against flatulence and bowel impairments. Active substance: domperidone)
- Reminyl (against Alzheimer’s disease (dementia). Active substance: galantamine)
- Daktarin (against fungal infections. Active substance: miconazole)
- Nizoral (against dandruff, Active substance: ketoconazole)
- Duragesic (fentanyl patch for pain suppression. Active substance: fentanyl)
- Vermox (against intestinal worms. Active substance: mebendazole)
- Risperdal (antipsychotic, against mental illness such as schizophrenia. Active substance: risperidone)
WHO Model List of Essential Medicines
Eight original Janssen drugs have been included on the WHO Model List of Essential Medicines:
- Imodium (loperamide)
- Haldol (haloperidol)
- Ergamisol (levamisole)
- Daktarin (miconazole)
- Vermox (mebendazole)
- Nizoral (ketoconazole) (Removed in 2005)
- Risperdal (risperidone)
- Sirturo (bedaquiline) – an diarylquinoline anti-tuberculosis drug, discovered by Koen Andries and his team, which promises a shorter and simpler treatment for multi-drug-resistant tuberculosis (MDR-TB).
Centocor products
In 1984, Centocor developed their first product approved by the U.S. Food and Drug Administration (FDA) — a diagnostic test used to detect the rabies virus.[citation needed]
In 1998, the company launched its top-selling monoclonal antibody Remicade (infliximab) for its first FDA approved indication in Crohn’s disease. Subsequently, Remicade’s market has expanded with approvals for rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, ulcerative colitis, and pediatric Crohn’s disease. Remicade was approved for plaque psoriasis in September 2006.
Centocor also markets ReoPro (abciximab), a biologic agent indicated as an adjunct to coronary angioplasty (PTCA).
In 2009, the U.S. FDA approved Simponi, a human monoclonal antibody for treatment for arthritis, which was co-developed with Medarex, Inc.[37]
Risperdal deception
In 2004, the United States Department of Justice began investigating sales practices surrounding the antipsychotic drug risperidone (Risperdal). In 2010, the agency joined a whistleblower suit alleging that despite being warned by the U.S. Food and Drug Administration not to promote Risperdal as effective and safe for elderly patients, in whom it was known to be associated with early death, Johnson & Johnson and Janssen Pharmaceuticals paid pharmacists at Omnicare, the largest supplier of pharmaceuticals to nursing homes, tens of millions of dollars in bribes and kickbacks to promote the drug to physicians for this unapproved use.[38][39]
The lawsuit resulted in a 2012 provisional settlement totaling $2.3 billion,[40] with Omnicare having already settled for around $100 million.[40] Four states were awarded damages: Louisiana ($258 million in 2010), South Carolina ($327 million in 2011), Texas ($158 million in 2012), and Arkansas ($1.2 billion in 2012).[41]
Former head of sales and president of Janssen Alex Gorsky, who according to the Department of Justice “was actively involved” in the fraud, became CEO of Johnson & Johnson in 2012.[42]
Johnson and Johnson a name you can trust—-NOT!!! Restored
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